Simple, fast and reliable spectrophotometric methods were developed for determination of cefadroxil in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in distilled water. The quantitative determination of the drug was carried out using the zero/0th, first and second order method values measured at 264, 268 and 268 nm respectively. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of cefadroxil using 5-25 μg/ml (r² = 0.9991, r² = 0.9950, r² = 0.9976) for zero, first and second order spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. The developed methods were successfully applied to estimate the amount of cefadroxil in pharmaceutical formulations.
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